Deficiency in mTORC1-controlled C/EBP?-mRNA translation improves metabolic health in mice.
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ABSTRACT:
SUBMITTER: Zidek LM
PROVIDER: S-EPMC4552494 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.
Zidek Laura M LM Ackermann Tobias T Hartleben Götz G Eichwald Sabrina S Kortman Gertrud G Kiehntopf Michael M Leutz Achim A Sonenberg Nahum N Wang Zhao-Qi ZQ von Maltzahn Julia J Müller Christine C Calkhoven Cornelis F CF
EMBO reports 20150625 8
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptations in response to changes in nutrient supply. Major downstream targets of mTORC1 signalling are the mRNA translation regulators p70 ribosomal protein S6 kinase 1 (S6K1p70) and the 4E-binding proteins (4E-BPs). However, little is known about vertebrate mRNAs that are specifically controlled by mTORC1 signalling and are engaged in regulating mTORC1-associated physiology. Here, we show that transla ...[more]
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