An Improved F(st) Estimator.
Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC4552798 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
An Improved F(st) Estimator.
Chen Guanjie G Yuan Ao A Shriner Daniel D Tekola-Ayele Fasil F Zhou Jie J Bentley Amy R AR Zhou Yanxun Y Wang Chuntao C Newport Melanie J MJ Adeyemo Adebowale A Rotimi Charles N CN
PloS one 20150828 8
The fixation index F(st) plays a central role in ecological and evolutionary genetic studies. The estimators of Wright ([Formula: see text]), Weir and Cockerham ([Formula: see text]), and Hudson et al. ([Formula: see text]) are widely used to measure genetic differences among different populations, but all have limitations. We propose a minimum variance estimator [Formula: see text] using [Formula: see text] and [Formula: see text]. We tested [Formula: see text] in simulations and applied it to ...[more]
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