Ontology highlight
ABSTRACT:
SUBMITTER: Tiwari KK
PROVIDER: S-EPMC4553106 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Tiwari Kirti Kumar KK Moorthy Bhagavatula B Lingappan Krithika K
Toxicology in vitro : an international journal published in association with BIBRA 20150521 7
GDF15 (growth and differentiation factor 15) is a secreted cytokine, a direct target of p53 and plays a role in cell proliferation and apoptosis. It is induced by oxidative stress and has anti-apoptotic effects. The role of GDF15 in hyperoxic lung injury is unknown. We tested the hypothesis that GDF15 will be induced in vitro, in a model of pulmonary oxygen toxicity, and will play a critical role in decreasing cell death and oxidative stress. BEAS-2B (human bronchial epithelial cells) and human ...[more]