Dataset Information

Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques.

ABSTRACT:

Objectives

This study analyzed the long-term hearing loss after treatment of primary nasopharyngeal carcinoma to elucidate its causal factors.

Methods

Ninety-two nasopharyngeal carcinoma patients were treated with radiotherapy or chemoradiotherapy. Pure tone audiometry was performed before the therapy and annually up to 9 years after completing treatment. The hearing thresholds were corrected for age-related deterioration and compared to the results without adjusting for age.

Results

The mean air and bone conduction threshold with and without correction for age-related deterioration differed significantly 2-9 years after completing radiotherapy (p < 0.05). The audiometry results with age correction showed a flattened configuration compared to the results without age correction. The total radiation dose and radiation modality showed a causal relationship with a greater incidence of hearing loss after therapy (p < 0.05). There was more deterioration in the air and bone hearing thresholds with conformal radiotherapy than intensity-modulated radiotherapy (p < 0.001). A radiation dose >72?cGy resulted in more severe hearing loss than <72?cGy (p < 0.05).

Conclusion

Hearing loss after completing therapy should be corrected for age-related hearing deterioration to reveal the true extent to which the loss is a therapeutic complication. Both the radiation modality used and the dose were significantly associated with hearing loss.

SUBMITTER: Hwang CF

PROVIDER: S-EPMC4553178 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques.

Hwang Chung-Feng CF Fang Fu-Min FM Zhuo Ming-Ying MY Yang Chao-Hui CH Yang Li-Na LN Hsieh Hui-Shan HS

BioMed research international 20150816

<h4>Objectives</h4>This study analyzed the long-term hearing loss after treatment of primary nasopharyngeal carcinoma to elucidate its causal factors.<h4>Methods</h4>Ninety-two nasopharyngeal carcinoma patients were treated with radiotherapy or chemoradiotherapy. Pure tone audiometry was performed before the therapy and annually up to 9 years after completing treatment. The hearing thresholds were corrected for age-related deterioration and compared to the results without adjusting for age.<h4>R ...[more]

PMID: 26351638

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Project description:PURPOSE:Comparing radiation treatment plans by using the same safety margins and dose objectives for all techniques, to ascertain the optimal radiation technique for the stereotactic body radiotherapy (SBRT) of low-risk prostate cancer. MATERIAL AND METHODS:Treatment plans for 27 randomly selected patients were compared using intensity-modulated (IMRT) techniques as Sliding Window (SW), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT), as well as Cyber Knife (CK) system. The target dose was calculated to 36.25?Gy delivered in five fractions over 1?week. Dosimetric indices for target volume and organs at risk (OAR) as well as normal tissue complication probability (NTCP) of late rectal and urinary bladder toxicities were analyzed. RESULTS:The CK provided lower homogeneity in the target volume, but higher values for most of the conformity indices compared to the IMRT approaches. The SW demonstrated superior rectum sparing at medium-to-high dose range (V18?Gy - V32.6?Gy) compared to other techniques (p <?0.05). The whole urinary bladder experienced the best shielding by SW and VMAT at the medium dose (V18?Gy, p <?0.05 versus CK), however we obtained no relevant differences between techniques at the high dose. Generally, the CK demonstrated significantly superior rectum and bladder exposure at V18?Gy as compared to HT, SW, and VMAT. For the rectum, mean NTCP values were significantly superior for HT (NTCP?=?2.3%, p <?0.05), and for urinary bladder, the NTCP showed no significant advantages for any technique. CONCLUSION:No absolute dosimetric advantage was revealed to choose between CK or IMRT techniques for the SBRT of low-grade prostate cancer. Using the same safety margins and dose objectives, IMRT techniques demonstrated superior sparing of the rectum and bladder at a medium dose compared to CK. Comparing different IMRT approaches SW displayed superior rectum sparing at a medium-to-high dose range, whereas both SW and RA revealed superior bladder sparing compared to HT. HT demonstrated a significantly lower NTCP outcome compared to CK or IMRT techniques regarding the rectum. Radiation plans can be optimized further by an individual modification of dose objectives independent of the treatment plan strategy.

Dataset Information

Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques.

Objectives

Methods

Results

Conclusion

Publications

Hearing Assessment after Treatment of Nasopharyngeal Carcinoma with CRT and IMRT Techniques.

Similar Datasets

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