Ontology highlight
ABSTRACT:
SUBMITTER: Yoon H
PROVIDER: S-EPMC4553406 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Yoon Heera H Jang Yong Ho YH Kim Sang Jeong SJ Lee Sung Joong SJ Kim Sun Kwang SK
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20150820 5
Microglia, the resident macrophages in the central nervous system, can rapidly respond to pathological insults. Toll-like receptor 2 (TLR2) is a pattern recognition receptor that plays a fundamental role in pathogen recognition and activation of innate immunity. Although many previous studies have suggested that TLR2 contributes to microglial activation and subsequent pathogenesis following brain tissue injury, it is still unclear whether TLR2 has a role in microglia dynamics in the resting stat ...[more]