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Modelling solubility of phenolics of mango ginger extract in supercritical carbon dioxide using equation of state and empirical models.

ABSTRACT: Solubility of phenolics of mango ginger extract in supercritical carbon dioxide was studied at 40-60 °C and 100-350 bar. Critical temperature, critical pressure and critical volume of caffeic acid, the principal component of the extract were calculated using group contribution methods and compared with the values obtained by CHEMDRAW®. Vapor pressure of caffeic acid was predicted by Reidel method. Solubility prediction in supercritical carbon dioxide was studied using two different equation of states (EOS) models and eight empirical models. Peng-Robinson EOS predicted the solubility very well with average deviation of 0.68 % from the experimental solubility. Empirical equations based on the simple error minimization using non-linear regression method which do not require complex physiochemical properties was also found suitable to predict the solubility at different extraction conditions. Jouyban et al. model showed very less deviation (2.25 %) for predicted solubility values from the experiment.

SUBMITTER: Murthy TP

PROVIDER: S-EPMC4554676 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Modelling solubility of phenolics of mango ginger extract in supercritical carbon dioxide using equation of state and empirical models.

Murthy Thirupathihalli Pandurangappa Krishna TP Manohar Balaraman B

Journal of food science and technology 20141211 9

Solubility of phenolics of mango ginger extract in supercritical carbon dioxide was studied at 40-60 °C and 100-350 bar. Critical temperature, critical pressure and critical volume of caffeic acid, the principal component of the extract were calculated using group contribution methods and compared with the values obtained by CHEMDRAW®. Vapor pressure of caffeic acid was predicted by Reidel method. Solubility prediction in supercritical carbon dioxide was studied using two different equation of s ...[more]

PMID: 26344969

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Project description:BackgroundAs a prevalent type of cryptogenic fibrotic disease with high mortality, idiopathic pulmonary fibrosis (IPF) still lacks effective therapeutic drugs. The compounds extracted from buds and flowers of Chrysanthemum indicum Linné with supercritical-carbon dioxide fluid (CISCFE) has been confirmed to have antioxidant, anti-inflammatory, and lung-protective effects. This paper aimed to clarify whether CISCFE could treat IPF induced by bleomycin (BLM) and elucidate the related mechanisms.MethodsRats (Sprague-Dawley, male) were separated into the following groups: normal, model, pirfenidone (50 mg/kg), CISCFE-L, -M, and -H (240, 360, and 480 mg/kg/d, i.g., respectively, for 4 weeks). Rats were given BLM (5 mg/kg) via intratracheal installation to establish the IPF model. A549 and MRC-5 cells were stimulated by Wnt-1 to establish a cell model and then treated with CISCFE. Haematoxylin-eosin (H&E) and Masson staining were employed to observe lesions in the lung tissues. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot (WB) were performed to observe changes in genes and proteins connected with the Wnt/β-catenin pathway.ResultsCISCFE inhibited the proliferation of MRC-5 cells (IC50: 2.723 ± 0.488 μg/mL) and A549 cells (IC50: 2.235 ± 0.229 μg/mL). In rats, A549 cells, and MRC-5 cells, BLM and Wnt-1 obviously induced the protein expression of α-smooth muscle actin (α-SMA), vimentin, type I collagen (collagen-I), and Nu-β-catenin. The mRNA levels of matrix metalloproteinase-3 (MMP-3) and - 9 (MMP-9), two enzymes that degrade and reshape the extracellular matrix (ECM) were also increased while those of tissue inhibitor of metalloproteinase 1 (TIMP-1) were decreased. However, CISCFE reversed the effects of BLM and Wnt-1 on the expression pattern of these proteins and genes.ConclusionThese findings showed that CISCFE could inhibit IPF development by activating the Wnt/β-catenin pathway and may serve as a treatment for IPF after further investigation.

Dataset Information

Modelling solubility of phenolics of mango ginger extract in supercritical carbon dioxide using equation of state and empirical models.

Publications

Modelling solubility of phenolics of mango ginger extract in supercritical carbon dioxide using equation of state and empirical models.

Similar Datasets

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