Ontology highlight
ABSTRACT:
SUBMITTER: Subei AM
PROVIDER: S-EPMC4554772 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
CNS drugs 20150701 7
Sphingosine 1-phosphate (S1P) receptor modulators possess a unique mechanism of action as disease-modifying therapy for multiple sclerosis (MS). Subtype 1 S1P receptors are expressed on the surfaces of lymphocytes and are important in regulating egression from lymph nodes. The S1P receptor modulators indirectly antagonize the receptor's function and sequester lymphocytes in lymph nodes. Fingolimod was the first S1P agent approved in the USA in 2010 for relapsing MS after two phase III trials (FR ...[more]