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Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism.

ABSTRACT: Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5-33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem's corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD.

SUBMITTER: Travers BG 

PROVIDER: S-EPMC4554823 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism.

Travers Brittany G BG   Bigler Erin D ED   Tromp Do P M do PM   Adluru Nagesh N   Destiche Dan D   Samsin Danica D   Froehlich Alyson A   Prigge Molly D B MD   Duffield Tyler C TC   Lange Nicholas N   Alexander Andrew L AL   Lainhart Janet E JE  

Journal of autism and developmental disorders 20150901 9

Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5-33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicte  ...[more]

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