Ontology highlight
ABSTRACT:
SUBMITTER: Swiderek K
PROVIDER: S-EPMC4554825 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Świderek K K Tuñón I I Moliner V V Bertran J J
Archives of biochemistry and biophysics 20150319
In this contribution, recent developments in the design of biocatalysts are reviewed with particular emphasis in the de novo strategy. Studies based on three different reactions, Kemp elimination, Diels-Alder and Retro-Aldolase, are used to illustrate different success achieved during the last years. Finally, a section is devoted to the particular case of designed metalloenzymes. As a general conclusion, the interplay between new and more sophisticated engineering protocols and computational met ...[more]