Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC4554971 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Wang Betsy B Li Kristin K Jin Max M Qiu Rongde R Liu Bo B Oakley Berl R BR Xiang Xin X
Fungal genetics and biology : FG & B 20150624
Centrosome amplification is a hallmark of many types of cancer cells, and clustering of multiple centrosomes is critical for cancer cell survival and proliferation. Human kinesin-14 HSET/KFIC1 is essential for centrosome clustering, and its inhibition leads to the specific killing of cancer cells with extra centrosomes. Since kinesin-14 motor domains are conserved evolutionarily, we conceived a strategy of obtaining kinesin-14 inhibitors using Aspergillus nidulans, based on the previous result t ...[more]