Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC4555174 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Sun Yulong Y Liu Jia J Jiang Xianxing X Sun Tao T Liu Luping L Zhang Xiaoyuan X Ding Shaoli S Li Jingyi J Zhuang Yan Y Wang Yiqing Y Wang Rui R
Scientific reports 20150901
Here we report a facile approach to synthesize highly optically active oxindole-type analogues with both high yield and enantioselectivity. This single-step synthesis strategy represents a substantial improvement upon existing methods that are often involved with multi-step routes and have suboptimal atomic economy. One such compound, namely Q4c, showed remarkable in vivo anti-inflammatory activity with efficiency approaching to that of a steroidal compound dexamethasone. Moreover, Q4c alleviate ...[more]