Ontology highlight
ABSTRACT:
SUBMITTER: Wan Z
PROVIDER: S-EPMC4555871 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Wan Zhengpeng Z Chen Xiangjun X Chen Haodong H Ji Qinghua Q Chen Yingjia Y Wang Jing J Cao Yiyun Y Wang Fei F Lou Jizhong J Tang Zhuo Z Liu Wanli W
eLife 20150810
B lymphocytes use B cell receptors (BCRs) to sense the physical features of the antigens. However, the sensitivity and threshold for the activation of BCRs resulting from the stimulation by mechanical forces are unknown. Here, we addressed this question using a double-stranded DNA-based tension gauge tether system serving as a predefined mechanical force gauge ranging from 12 to 56 pN. We observed that IgM-BCR activation is dependent on mechanical forces and exhibits a multi-threshold effect. In ...[more]