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Structure of the 14-3-3?-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3.

ABSTRACT: The 14-3-3 proteins are a family of highly conserved proteins that play key roles in many cellular processes. The tumour suppressor LKB1 regulates cell polarity, cell growth and energy metabolism. 14-3-3 proteins bind to LKB1 and suppress its functions. Previously, preliminary crystallographic data for the 14-3-3?-LKB1 fusion protein have been reported. Here, the crystal structure of this fusion protein was solved and a novel potential binding mode of 14-3-3 to its ligands was found.

SUBMITTER: Ding S

PROVIDER: S-EPMC4555915 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Structure of the 14-3-3ζ-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3.

Ding Sheng S Zhou Ruiqing R Zhu Yaqin Y

Acta crystallographica. Section F, Structural biology communications 20150825 Pt 9

The 14-3-3 proteins are a family of highly conserved proteins that play key roles in many cellular processes. The tumour suppressor LKB1 regulates cell polarity, cell growth and energy metabolism. 14-3-3 proteins bind to LKB1 and suppress its functions. Previously, preliminary crystallographic data for the 14-3-3ζ-LKB1 fusion protein have been reported. Here, the crystal structure of this fusion protein was solved and a novel potential binding mode of 14-3-3 to its ligands was found. ...[more]

PMID: 26323294

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