Ontology highlight
ABSTRACT:
SUBMITTER: Baik JY
PROVIDER: S-EPMC4556170 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Baik Jong Youn JY Dahodwala Hussain H Oduah Eziafa E Talman Lee L Gemmill Trent R TR Gasimli Leyla L Datta Payel P Yang Bo B Li Guoyun G Zhang Fuming F Li Lingyun L Linhardt Robert J RJ Campbell Andrew M AM Gorfien Stephen F SF Sharfstein Susan T ST
Biotechnology journal 20150624 7
Heparin is the most widely used anticoagulant drug in the world today. Heparin is currently produced from animal tissues, primarily porcine intestines. A recent contamination crisis motivated development of a non-animal-derived source of this critical drug. We hypothesized that Chinese hamster ovary (CHO) cells could be metabolically engineered to produce a bioengineered heparin, equivalent to current pharmaceutical heparin. We previously engineered CHO-S cells to overexpress two exogenous enzym ...[more]