Ontology highlight
ABSTRACT:
SUBMITTER: Wikan N
PROVIDER: S-EPMC4556410 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Wikan Nitwara N Libsittikul Sirikwan S Yoksan Sutee S Auewarakul Prasert P Smith Duncan R DR
BMC research notes 20150902
<h4>Background</h4>The concept of antibody dependent enhancement (ADE) of dengue virus (DENV) infection is a cornerstone of our current understanding of dengue pathogenesis, although some questions as to the mechanism remain, particularly in regards to the behavior of low and high passage virus isolates. This study utilized two low passage DENV 4 isolates and a laboratory adapted DENV 4 isolate to investigate the potential of low passage isolates to undergo ADE.<h4>Results</h4>Little or no ADE o ...[more]