Ontology highlight
ABSTRACT:
SUBMITTER: Tsuji T
PROVIDER: S-EPMC4556649 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Tsuji Toshiya T Lau Eric E Chiang Gary G GG Jiang Wei W
Molecular cell 20081201 6
The Dbf4/Drf1-dependent S-phase-promoting kinase Cdc7 (Ddk) is thought to be an essential target inactivated by the S-phase checkpoint machinery that inhibits DNA replication. However, we show here that the complex formation, chromatin association, and kinase activity of Ddk are not inhibited during the DNA-damage-induced S-phase checkpoint response in Xenopus egg extracts and mammalian cells. Instead, we find that Ddk plays an active role in regulating S-phase checkpoint signaling. Addition of ...[more]