Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents.
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ABSTRACT:
SUBMITTER: Moseley RL
PROVIDER: S-EPMC4556734 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents.
Moseley R L RL Ypma R J F RJ Holt R J RJ Floris D D Chura L R LR Spencer M D MD Baron-Cohen S S Suckling J J Bullmore E E Rubinov M M
NeuroImage. Clinical 20150807
Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs). We studied well-matched groups of adolescent males with autism, genetically-related siblings of individuals with autism, and typically-developing control participants. We parcellated the brain into 258 regions and used complex-network analysis t ...[more]
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