Ontology highlight
ABSTRACT:
SUBMITTER: Noto R
PROVIDER: S-EPMC4556959 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Noto Rosina R Randazzo Loredana L Raccosta Samuele S Caccia Sonia S Moriconi Claudia C Miranda Elena E Martorana Vincenzo V Manno Mauro M
Scientific reports 20150902
Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), a genetic neurodegenerative disease caused by accumulation of NS polymers. Our Molecular Dynamics simulations revealed the formation of a persistent salt bridge between Glu289 on strand s2C and Arg362 on the Reactive Centre Loop (RCL), a region important for the inhibitory activity of NS. Here, we v ...[more]