Ontology highlight
ABSTRACT:
SUBMITTER: Liesveld JL
PROVIDER: S-EPMC4557209 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Liesveld Jane L JL Rosell Karen E KE Bechelli Jeremy J Lu Chaohui C Messina Patti P Mulford Deborah D Ifthikharuddin J J JJ Jordan Craig T CT Phillips Ii Gordon L GL
Cancer investigation 20110801 7
In this work, effects of bortezomib on apoptosis, clonal progenitor growth, cytokine production, and NF-κB expression in patients with MDS with cytopenias requiring transfusion support are examined. Bortezomib increased apoptosis in marrow mononuclear cells but had no effects on CFU-GM, BFU-E, or CFU-L content. No consistent effects on NF-κB activation in vivo were noted. To further define the role of bortezomib in AML and MDS, we examined it in combination with several targeted agents and chemo ...[more]