Ontology highlight
ABSTRACT:
SUBMITTER: Oddsson A
PROVIDER: S-EPMC4557269 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Nature communications 20150814
Kidney stone disease is a complex disorder with a strong genetic component. We conducted a genome-wide association study of 28.3 million sequence variants detected through whole-genome sequencing of 2,636 Icelanders that were imputed into 5,419 kidney stone cases, including 2,172 cases with a history of recurrent kidney stones, and 279,870 controls. We identify sequence variants associating with kidney stones at ALPL (rs1256328[T], odds ratio (OR)=1.21, P=5.8 × 10(-10)) and a suggestive associat ...[more]