Ontology highlight
ABSTRACT:
SUBMITTER: Oddsson A
PROVIDER: S-EPMC4557269 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Oddsson Asmundur A Sulem Patrick P Helgason Hannes H Edvardsson Vidar O VO Thorleifsson Gudmar G Sveinbjörnsson Gardar G Haraldsdottir Eik E Eyjolfsson Gudmundur I GI Sigurdardottir Olof O Olafsson Isleifur I Masson Gisli G Holm Hilma H Gudbjartsson Daniel F DF Thorsteinsdottir Unnur U Indridason Olafur S OS Palsson Runolfur R Stefansson Kari K
Nature communications 20150814
Kidney stone disease is a complex disorder with a strong genetic component. We conducted a genome-wide association study of 28.3 million sequence variants detected through whole-genome sequencing of 2,636 Icelanders that were imputed into 5,419 kidney stone cases, including 2,172 cases with a history of recurrent kidney stones, and 279,870 controls. We identify sequence variants associating with kidney stones at ALPL (rs1256328[T], odds ratio (OR)=1.21, P=5.8 × 10(-10)) and a suggestive associat ...[more]