Ontology highlight
ABSTRACT:
SUBMITTER: Sahoo A
PROVIDER: S-EPMC4557271 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Sahoo Anupama A Alekseev Andrei A Tanaka Kentaro K Obertas Lidiya L Lerman Beatrisa B Haymaker Cara C Clise-Dwyer Karen K McMurray John S JS Nurieva Roza R
Nature communications 20150817
Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL-4 production in Tfh cells remains mainly unknown. Here, we show that the basic leucine zipper transcription factor ATF-like, Batf is important for IL-4 expression in Tfh cells rather than in canonical Th2 cells. Functionally, Batf in cooperation with interferon regulatory factor (IRF) 4 along with ...[more]