Exosome-delivered microRNAs modulate the inflammatory response to endotoxin.
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ABSTRACT:
SUBMITTER: Alexander M
PROVIDER: S-EPMC4557301 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin.
Alexander Margaret M Hu Ruozhen R Runtsch Marah C MC Kagele Dominique A DA Mosbruger Timothy L TL Tolmachova Tanya T Seabra Miguel C MC Round June L JL Ward Diane M DM O'Connell Ryan M RM
Nature communications 20150618
MicroRNAs regulate gene expression posttranscriptionally and function within the cells in which they are transcribed. However, recent evidence suggests that microRNAs can be transferred between cells and mediate target gene repression. We find that endogenous miR-155 and miR-146a, two critical microRNAs that regulate inflammation, are released from dendritic cells within exosomes and are subsequently taken up by recipient dendritic cells. Following uptake, exogenous microRNAs mediate target gene ...[more]
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