Unknown

Dataset Information

0

Hepatitis B virus (HBV) X gene diversity and evidence of recombination in HBV/HIV co-infected persons.


ABSTRACT: The high frequency of mutation during hepatitis B virus (HBV) infection has resulted in 8 genotypes (A-H) with varying effects on disease severity and treatment efficacy. However, analysis of intrapatient HBV diversity is limited, especially during HIV co-infection. Therefore, a preliminary study was performed to analyze HBV X gene diversity in 17 HBV/HIV co-infected individuals. Phylogenetic analysis revealed HBV genotype A in 13 individuals (76.5%) or genotype E in 1 individual (5.9%). Additionally, 3 individuals were dually infected with HBV genotypes A and G (17.6%). Overall, higher genetic distance and entropy were observed in the X region and overlapping polymerase (Pol(X)) regions when compared to the PreS, S, and overlapping polymerase (Pol(PS) and Pol(S)) regions analyzed in the same patients as part of a previous study. In addition, multiple viral variants from 2 individuals with dual HBV infection did not group with either genotype A or G by phylogenetic analysis, indicating possible recombination. SimPlot bootscan analysis confirmed recombination breakpoints within the X gene in both individuals. Recombination between HBV genotypes may represent an important evolutionary strategy that enhances overall pathogenic potential and/or alters the downstream effects of the HBV X protein.

SUBMITTER: Martin CM 

PROVIDER: S-EPMC4557641 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Hepatitis B virus (HBV) X gene diversity and evidence of recombination in HBV/HIV co-infected persons.

Martin Christina M CM   Welge Jeffrey A JA   Blackard Jason T JT  

Journal of medical virology 20110422 7


The high frequency of mutation during hepatitis B virus (HBV) infection has resulted in 8 genotypes (A-H) with varying effects on disease severity and treatment efficacy. However, analysis of intrapatient HBV diversity is limited, especially during HIV co-infection. Therefore, a preliminary study was performed to analyze HBV X gene diversity in 17 HBV/HIV co-infected individuals. Phylogenetic analysis revealed HBV genotype A in 13 individuals (76.5%) or genotype E in 1 individual (5.9%). Additio  ...[more]

Similar Datasets

| S-EPMC5586040 | biostudies-literature
| S-EPMC5938795 | biostudies-literature
| S-EPMC7485811 | biostudies-literature
| S-EPMC5953819 | biostudies-literature
| S-EPMC7790253 | biostudies-literature
| S-EPMC3409123 | biostudies-literature
| S-EPMC4577215 | biostudies-literature
| S-EPMC7966718 | biostudies-literature
| S-EPMC6128547 | biostudies-literature
| S-EPMC516776 | biostudies-literature