Ontology highlight
ABSTRACT:
SUBMITTER: Nemeth K
PROVIDER: S-EPMC4557871 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nemeth Krisztian K Wilson Todd M TM Ren Jiaqiang J JJ Sabatino Marianna M Stroncek David M DM Krepuska Miklos M Bai Yun Y Robey Pamela G PG Metcalfe Dean D DD Mezey Eva E
Stem cell research 20150508 1
Patients with systemic mastocytosis (SM) have a wide variety of problems, including skeletal abnormalities. The disease results from a mutation of the stem cell receptor (c-kit) in mast cells and we wondered if the function of bone marrow stromal cells (BMSCs; also known as MSCs or mesenchymal stem cells) might be affected by the invasion of bone marrow by mutant mast cells. As expected, BMSCs from SM patients do not have a mutation in c-kit, but they proliferate poorly. In addition, while osteo ...[more]