Ontology highlight
ABSTRACT:
SUBMITTER: Lee TJ
PROVIDER: S-EPMC4558114 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Oncotarget 20150601 17
Systemic siRNA administration to target and treat glioblastoma, one of the most deadly cancers, requires robust and efficient delivery platform without immunogenicity. Here we report newly emerged multivalent naked RNA nanoparticle (RNP) based on pRNA 3-way-junction (3WJ) from bacteriophage phi29 to target glioblastoma cells with folate (FA) ligand and deliver siRNA for gene silencing. Systemically injected FA-pRNA-3WJ RNPs successfully targeted and delivered siRNA into brain tumor cells in mice ...[more]