Ontology highlight
ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC4558131 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Du Juan J Liu Shuyan S He Jie J Liu Xi X Qu Ying Y Yan Wenqing W Fan Jianling J Li Rong R Xi Hao H Fu Weijun W Zhang Chunyang C Yang Jing J Hou Jian J
Oncotarget 20150601 17
Side population (SP) cells are an enriched source of cancer-initiating cells with stemness characteristics, generated by increased ABC transporter activity, which has served as a unique hallmark for multiple myeloma (MM) stem cell studies. Here we isolated and identified MM SP cells via Hoechst 33342 staining. Furthermore, we demonstrate that SP cells possess abnormal cell cycle, clonogenicity, and high drug efflux characteristics-all of which are features commonly seen in stem cells. Interestin ...[more]