Ontology highlight
ABSTRACT:
SUBMITTER: Lauenborg B
PROVIDER: S-EPMC4558148 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Lauenborg Britt B Christensen Louise L Ralfkiaer Ulrik U Kopp Katharina L KL Jønson Lars L Dabelsteen Sally S Bonefeld Charlotte M CM Geisler Carsten C Gjerdrum Lise Mette R LM Zhang Qian Q Wasik Mariusz A MA Ralfkiaer Elisabeth E Ødum Niels N Woetmann Anders A
Oncotarget 20150601 17
Lymphotoxin α (LTα) plays a key role in the formation of lymphatic vasculature and secondary lymphoid structures. Cutaneous T cell lymphoma (CTCL) is the most common primary lymphoma of the skin and in advanced stages, malignant T cells spreads through the lymphatic to regional lymph nodes to internal organs and blood. Yet, little is known about the mechanism of the CTCL dissemination. Here, we show that CTCL cells express LTα in situ and that LTα expression is driven by aberrantly activated JAK ...[more]