Ontology highlight
ABSTRACT:
SUBMITTER: Zhao M
PROVIDER: S-EPMC4558174 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Zhao Mengyang M Fang Weiyi W Wang Yan Y Guo Suiqun S Shu Luyun L Wang Lijing L Chen YiYu Y Fu Qiaofen Q Liu Yan Y Hua Shengni S Fan Yue Y Liu Yiyi Y Deng Xiaojie X Luo Rongcheng R Mei Zhong Z Jiang Qinping Q Liu Zhen Z
Oncotarget 20150601 17
ENO1 plays a paradoxical role in driving the pathogenesis of tumors. However, the clinical significance of ENO1 expression remains unclear and its function and modulatory mechanisms have never been reported in endometrial carcinoma (EC). In this study, ENO1 silencing significantly reduced cell glycolysis, proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo by modulating p85 suppression. This in turn mediated inactivation of PI3K/AKT signaling and its ...[more]