Circadian Dysfunction Induces Leptin Resistance in Mice.
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ABSTRACT:
SUBMITTER: Kettner NM
PROVIDER: S-EPMC4558341 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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Circadian Dysfunction Induces Leptin Resistance in Mice.
Kettner Nicole M NM Mayo Sara A SA Hua Jack J Lee Choogon C Moore David D DD Fu Loning L
Cell metabolism 20150709 3
Circadian disruption is associated with obesity, implicating the central clock in body weight control. Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and physiologic interventions differentially disrupt overall energy homeostasis and Leptin signaling. We found that BMAL1/CLOCK generates circadian rhythm of C/EBPα-mediated leptin transcription in adipose. Per and Cry mutant mice show similar disruption of ...[more]
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