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Synergistic Effects of SDF-1? and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair.

ABSTRACT: In order to achieve bone repair, bone morphogenetic protein-2 (BMP-2) is typically delivered in non-physiological doses and can result in significant adverse side effects. To reduce the amount of BMP-2 necessary for bone formation, we delivered a known chemokine (stromal cell derived factor-1?, SDF-1?) in combination with BMP-2 using proteolytically degradable hydrogels. A critical-sized calvarial defect was used to determine the effect of biomolecule delivery on bone formation in vivo. The treatment group with combined SDF-1? and BMP-2 hydrogel delivery showed significantly higher bone formation when compared to hydrogels loaded with the same BMP-2 or SDF-1? concentrations alone, suggesting the combined delivery of both biomolecules synergistically improves osteogenesis.

SUBMITTER: Holloway JL

PROVIDER: S-EPMC4558375 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair.

Holloway Julianne L JL Ma Henry H Rai Reena R Hankenson Kurt D KD Burdick Jason A JA

Macromolecular bioscience 20150608 9

In order to achieve bone repair, bone morphogenetic protein-2 (BMP-2) is typically delivered in non-physiological doses and can result in significant adverse side effects. To reduce the amount of BMP-2 necessary for bone formation, we delivered a known chemokine (stromal cell derived factor-1α, SDF-1α) in combination with BMP-2 using proteolytically degradable hydrogels. A critical-sized calvarial defect was used to determine the effect of biomolecule delivery on bone formation in vivo. The trea ...[more]

PMID: 26059079

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