Ontology highlight
ABSTRACT:
SUBMITTER: Hurtado AM
PROVIDER: S-EPMC4558590 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hurtado A M AM Chen-Liang T-H TH Przychodzen B B Hamedi C C Muñoz-Ballester J J Dienes B B García-Malo M D MD Antón A I AI de Arriba F F Teruel-Montoya R R Ortuño F J FJ Vicente V V Maciejewski J P JP Jerez A A
Blood cancer journal 20150828
An increasing numbers of patients are being diagnosed with asymptomatic early-stage chronic lymphocytic leukemia (CLL), with no treatment indication at baseline. We applied a high-throughput deep-targeted analysis, especially designed for covering widely TP53 and ATM genes, in 180 patients with inactive disease at diagnosis, to test the independent prognostic value of CLL somatic recurrent mutations. We found that 40/180 patients harbored at least one acquired variant with ATM (n=17, 9.4%), NOTC ...[more]