Dataset Information

Increased Risk of Asthma in Children with ADHD: Role of Prematurity and Maternal Stress during Pregnancy.

ABSTRACT: OBJECTIVE:ADHD and asthma are prevalent conditions in childhood, with complex pathophysiology involving genetic-environmental interplay. The study objective is to examine the prevalence of asthma in our ADHD population and explore factors that may increase the risk of developing asthma in children with ADHD. METHODS:We retrospectively analyzed the presence of maternal stress during pregnancy and history of asthma in 201 children diagnosed with ADHD. RESULTS:Chi-square analysis indicated significant higher presence of asthma in our ADHD sample compared to Quebec children, ?(2)(1, N = 201) = 15.37, P<0.001. Only prematurity and stress during pregnancy significantly predicted asthma in a logistic regression model, ?(2)(2)=23.70, P<0.001, with odds ratios of 10.6 (95% CI: 2.8-39.5) and 3.2 (95% CI: 1.4-7.3), respectively. CONCLUSION:Children with ADHD have a higher prevalence of asthma than the general Quebec pediatric population. Children with ADHD born prematurely and/or those whose mothers experienced stress during pregnancy have a significantly increased risk of developing asthma. The study highlights the importance of potentially offering social and psychological support to mothers who experienced stress during pregnancy and/or are at risk of delivering prematurely.

SUBMITTER: Grizenko N

PROVIDER: S-EPMC4558981 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Increased Risk of Asthma in Children with ADHD: Role of Prematurity and Maternal Stress during Pregnancy.

Grizenko Natalie N Osmanlliu Esli E Fortier Marie-Ève MÈ Joober Ridha R

Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent 20150831 2

<h4>Objective</h4>ADHD and asthma are prevalent conditions in childhood, with complex pathophysiology involving genetic-environmental interplay. The study objective is to examine the prevalence of asthma in our ADHD population and explore factors that may increase the risk of developing asthma in children with ADHD.<h4>Methods</h4>We retrospectively analyzed the presence of maternal stress during pregnancy and history of asthma in 201 children diagnosed with ADHD.<h4>Results</h4>Chi-square analy ...[more]

PMID: 26379722

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Project description:BACKGROUND:Identifying modifiable risk factors for neuropsychological correlates of attention deficit hyperactivity disorder (ADHD) in early childhood can inform prevention strategies. Prenatal inflammatory states, such as maternal asthma and other atopic disorders, have been increasingly linked to enhanced risk for neurobehavioral disorders in children, with some studies suggesting sex-specific effects. OBJECTIVES:To assess the association between maternal active asthma and/or atopy in the antenatal period and child symptoms of ADHD during mid-childhood and, given the male-bias in ADHD prevalence, to examine modifying effects of child sex. STUDY DESIGN:The study sample includes 250 maternal-child pairs enrolled in the Boston-based Asthma Coalition on Community, Environment and Social Stress (ACCESS) pregnancy cohort. We defined antenatal active atopy based on maternal report of current asthma, allergic rhinitis or atopic dermatitis during and/or in the year before pregnancy. When children were approximately 6?years old, mothers completed a battery of standardized child behavior rating scales designed for evaluating symptoms of ADHD. We used multivariable quantile regression to assess the relations between maternal antenatal atopy and symptoms of ADHD among children. RESULTS:In adjusted models, maternal atopy was significantly associated with greater risk for ADHD behaviors, as indicated by scores on the Conners' Parent Rating Scale-Revised ADHD index (??=?3.32, 95% CI: 0.33, 6.32). In sex-stratified models this association was stronger among girls (5.96, 95% CI?=?0.95, 10.96) compared to boys (-2.14, 95% CI?=?-5.75, 1.45, p-interaction?=?0.01). Among girls, we observed a similar finding for the Behavior Assessment System for Children 2nd Edition Parent Rating Scale Attention Problems subscale (??=?7.77, 95% CI?=?1.57, 13.97). Results from other outcome subscales were similar in magnitude and direction, however, associations did not reach statistical significance at the p?=?0.05 level. CONCLUSIONS:Maternal antenatal active atopy may be a risk factor for the development of ADHD-like symptoms, especially among girls.

Dataset Information

Increased Risk of Asthma in Children with ADHD: Role of Prematurity and Maternal Stress during Pregnancy.

Publications

Increased Risk of Asthma in Children with ADHD: Role of Prematurity and Maternal Stress during Pregnancy.

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