Ontology highlight
ABSTRACT:
SUBMITTER: dos Santos RN
PROVIDER: S-EPMC4559900 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
dos Santos Ricardo N RN Morcos Faruck F Jana Biman B Andricopulo Adriano D AD Onuchic José N JN
Scientific reports 20150904
We develop a procedure to characterize the association of protein structures into homodimers using coevolutionary couplings extracted from Direct Coupling Analysis (DCA) in combination with Structure Based Models (SBM). Identification of dimerization contacts using DCA is more challenging than intradomain contacts since direct couplings are mixed with monomeric contacts. Therefore a systematic way to extract dimerization signals has been elusive. We provide evidence that the prediction of homodi ...[more]