Ontology highlight
ABSTRACT:
SUBMITTER: Maity TK
PROVIDER: S-EPMC4560174 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Maity Tapan K TK Venugopalan Abhilash A Linnoila Ilona I Cultraro Constance M CM Giannakou Andreas A Nemati Roxanne R Zhang Xu X Webster Joshua D JD Ritt Daniel D Ghosal Sarani S Hoschuetzky Heinz H Simpson R Mark RM Biswas Romi R Politi Katerina K Morrison Deborah K DK Varmus Harold E HE Guha Udayan U
Cancer discovery 20150303 5
<h4>Unlabelled</h4>Somatic mutations in the EGFR kinase domain drive lung adenocarcinoma. We have previously identified MIG6, an inhibitor of ERBB signaling and a potential tumor suppressor, as a target for phosphorylation by mutant EGFRs. Here, we demonstrate that MIG6 is a tumor suppressor for the initiation and progression of mutant EGFR-driven lung adenocarcinoma in mouse models. Mutant EGFR-induced lung tumor formation was accelerated in Mig6-deficient mice, even with Mig6 haploinsufficienc ...[more]