Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions.
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ABSTRACT:
SUBMITTER: Altafini C
PROVIDER: S-EPMC4560427 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions.
Altafini Claudio C Facchetti Giuseppe G
PLoS computational biology 20150904 9
In simple organisms like E.coli, the metabolic response to an external perturbation passes through a transient phase in which the activation of a number of latent pathways can guarantee survival at the expenses of growth. Growth is gradually recovered as the organism adapts to the new condition. This adaptation can be modeled as a process of repeated metabolic adjustments obtained through the resilencings of the non-essential metabolic reactions, using growth rate as selection probability for th ...[more]
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