Ontology highlight
ABSTRACT:
SUBMITTER: Lee YN
PROVIDER: S-EPMC4560976 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Lee Yu-Na YN Kim Min-Chul MC Lee Young-Tae YT Kim Yu-Jin YJ Lee Jongsang J Kim Cheol C Ha Suk-Hoon SH Kang Sang-Moo SM
Antiviral research 20150804
Current influenza vaccines are less efficacious against antigenically different influenza A viruses. This study presents an approach to overcome strain-specific protection, using a strategy of co-immunization with seasonal H3N2 split vaccine and yeast-expressed soluble proteins of a tandem repeat containing heterologous influenza M2 ectodomains (M2e5x). Co-immunization with both vaccines in mice was superior to either vaccine alone in inducing cross protection against heterologous H3N2 virus by ...[more]