X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells.
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ABSTRACT:
SUBMITTER: Pintacuda G
PROVIDER: S-EPMC4561061 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells.
Pintacuda Greta G Cerase Andrea A
Stem cell reviews and reports 20151001 5
X chromosome inactivation (XCI) is the dosage compensation mechanism that evolved in female mammals to correct the genetic imbalance of X-linked genes between sexes. X chromosome inactivation occurs in early development when one of the two X chromosomes of females is nearly-completely silenced. Differentiating Embryonic Stem cells (ESC) are regarded as a useful tool to study XCI, since they recapitulate many events occurring during early development. In this review we aim to summarise the advanc ...[more]
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