LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells.
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ABSTRACT:
SUBMITTER: Maki Y
PROVIDER: S-EPMC4561374 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells.
Maki Yuho Y Fujimoto Junya J Lang Wenhua W Xu Li L Behrens Carmen C Wistuba Ignacio I II Kadara Humam H
Scientific reports 20150907
We recently demonstrated that lysosomal protein transmembrane 4 beta (LAPTM4B) is elevated in non-small cell lung cancers (NSCLCs) and in the surrounding premalignant airway field of cancerization. In the present study, we sought to begin to understand the relevance of LAPTM4B expression and signaling to NSCLC pathogenesis. In situ hybridization analysis of LAPTM4B transcript in tissue microarrays comprised of 368 NSCLCs demonstrated that LAPTM4B expression was significantly increased in smoker ...[more]
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