Ontology highlight
ABSTRACT:
SUBMITTER: Coady TH
PROVIDER: S-EPMC4561479 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Coady Tristan H TH Manley James L JL
Genes & development 20150806 16
Amyotrophic lateral sclerosis (ALS) is caused by mutations in a number of genes, including the gene encoding the RNA/DNA-binding protein translocated in liposarcoma or fused in sarcoma (TLS/FUS or FUS). Previously, we identified a number of FUS target genes, among them MECP2. To investigate how ALS mutations in FUS might impact target gene expression, we examined the effects of several FUS derivatives harboring ALS mutations, such as R521C (FUS(C)), on MECP2 expression in transfected human U87 c ...[more]