Population Pharmacokinetic Model Characterizing 24-Hour Variation in the Pharmacokinetics of Oral and Intravenous Midazolam in Healthy Volunteers.
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SUBMITTER: van Rongen A
PROVIDER: S-EPMC4562161 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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Population Pharmacokinetic Model Characterizing 24-Hour Variation in the Pharmacokinetics of Oral and Intravenous Midazolam in Healthy Volunteers.
van Rongen A A Kervezee L L Brill Mje M van Meir H H den Hartigh J J Guchelaar H-J HJ Meijer J H JH Burggraaf J J van Oosterhout F F
CPT: pharmacometrics & systems pharmacology 20150724 8
Daily rhythms in physiology may affect the pharmacokinetics of a drug. The aim of this study was to evaluate 24-hour variation in the pharmacokinetics of the CYP3A substrate midazolam. Oral (2 mg) and intravenous (1 mg) midazolam was administered at six timepoints throughout the 24-hour period in 12 healthy volunteers. Oral bioavailability (population mean value [RSE%] of 0.28 (7.1%)) showed 24-hour variation that was best parameterized as a cosine function with an amplitude of 0.04 (17.3%) and ...[more]
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