Ontology highlight
ABSTRACT:
SUBMITTER: Du L
PROVIDER: S-EPMC4562164 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20150706 8
We propose to study a novel pharmacovigilance problem for mining directional effects of high-order drug interactions on an adverse drug event (ADE). Our goal is to estimate each individual risk of adding a new drug to an existing drug combination. In this proof-of-concept study, we analyzed a large electronic medical records database and extracted myopathy-relevant case control drug co-occurrence data. We applied frequent itemset mining to discover frequent drug combinations within the extracted ...[more]