Urinary Neutrophil Gelatinase-Associated Lipocalin to Monitor Lupus Nephritis Disease Activity.
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ABSTRACT: Background
This study was conducted to determine whether there is an association between urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary transforming growth factor-?1 (uTGF-?1) with lupus nephritis (LN) disease activity.Methods
Urine samples from 18 LN patients were collected every month for six months then examined for uNGAL, uTGF-?1, and renal domain Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score.Results
The uNGAL levels were significantly different between active and inactive LN (P < 0.05). uTGF-?1 levels were not different between active and inactive LN (P < 0.05). There was a significant correlation between uNGAL levels and renal domain SLEDAI score (r = 0.417, P < 0.05). There was no correlation between uTGF-?1 levels and renal domain SLEDAI score (r = 0.031, P < 0.05).Conclusion
uNGAL is better than uTGF-?1 for differentiation of active and inactive LN. uNGAL can be considered as a biomarker to monitor LN disease activity.
SUBMITTER: Susianti H
PROVIDER: S-EPMC4562555 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Urinary Neutrophil Gelatinase-Associated Lipocalin to Monitor Lupus Nephritis Disease Activity.
Susianti Hani H Wijaya Jullyanny W JW Rastini Ati A Handono Kusworini K Gunawan Atma A Kalim Handono H
Biomarker insights 20150906
<h4>Background</h4>This study was conducted to determine whether there is an association between urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary transforming growth factor-β1 (uTGF-β1) with lupus nephritis (LN) disease activity.<h4>Methods</h4>Urine samples from 18 LN patients were collected every month for six months then examined for uNGAL, uTGF-β1, and renal domain Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score.<h4>Results</h4>The uNGAL levels were s ...[more]
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