Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC4562799 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Li Mi M Pehar Mariana M Liu Yan Y Bhattacharyya Anita A Zhang Su-Chun SC O'Riordan Kenneth J KJ Burger Corinna C D'Adamio Luciano L D'Adamio Luciano L Puglielli Luigi L
Neurobiology of aging 20150621 10
p44 is a short isoform of the tumor suppressor protein p53 that is regulated in an age-dependent manner. When overexpressed in the mouse, it causes a progeroid phenotype that includes premature cognitive decline, synaptic defects, and hyperphosphorylation of tau. The hyperphosphorylation of tau has recently been linked to the ability of p44 to regulate transcription of relevant tau kinases. Here, we report that the amyloid precursor protein (APP) intracellular domain (AICD), which results from t ...[more]