The APP A673T frequency differs between Nordic countries.
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ABSTRACT:
SUBMITTER: Mengel-From J
PROVIDER: S-EPMC4562869 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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The APP A673T frequency differs between Nordic countries.
Mengel-From Jonas J Jeune Bernard B Pentti Tienari T McGue Matt M Christensen Kaare K Christiansen Lene L
Neurobiology of aging 20150711 10
A coding gene variant A673T (rs63750847) in the APP gene has recently been recognized as a protective variant of late-onset Alzheimer's Disease in a large Icelandic population and has been observed recurrently in populations from Nordic countries. The variant also was related to longevity in the Icelandic population. However, because of the extreme rarity of A673T in non-Nordic populations, the association with Alzheimer's disease has not yet been formally replicated. Because the variant has not ...[more]
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