Ontology highlight
ABSTRACT:
SUBMITTER: Dikovskaya D
PROVIDER: S-EPMC4562906 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Dikovskaya Dina D Cole John J JJ Mason Susan M SM Nixon Colin C Karim Saadia A SA McGarry Lynn L Clark William W Hewitt Rachael N RN Sammons Morgan A MA Zhu Jiajun J Athineos Dimitris D Leach Joshua D G JD Marchesi Francesco F van Tuyn John J Tait Stephen W SW Brock Claire C Morton Jennifer P JP Wu Hong H Berger Shelley L SL Blyth Karen K Adams Peter D PD
Cell reports 20150820 9
Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown. Here, we show that multinucleate OIS cells originate mostly from failed mitosis. Prior to senescence, mutant H-RasV12 activation in primary human fibroblasts compromised mitosis, concordant with abnormal expression of mitotic genes functionally linked to the observed mitotic ...[more]