Ontology highlight
ABSTRACT:
SUBMITTER: Gottfried C
PROVIDER: S-EPMC4563148 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Gottfried Carmem C Bambini-Junior Victorio V Francis Fiona F Riesgo Rudimar R Savino Wilson W
Frontiers in psychiatry 20150909
Autism spectrum disorder (ASD) involves a complex interplay of both genetic and environmental risk factors, with immune alterations and synaptic connection deficiency in early life. In the past decade, studies of ASD have substantially increased, in both humans and animal models. Immunological imbalance (including autoimmunity) has been proposed as a major etiological component in ASD, taking into account increased levels of pro-inflammatory cytokines observed in postmortem brain from patients, ...[more]