Ontology highlight
ABSTRACT:
SUBMITTER: Schallner N
PROVIDER: S-EPMC4563677 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Schallner Nils N Pandit Rambhau R LeBlanc Robert R Thomas Ajith J AJ Ogilvy Christopher S CS Zuckerbraun Brian S BS Gallo David D Otterbein Leo E LE Hanafy Khalid A KA
The Journal of clinical investigation 20150526 7
Subarachnoid hemorrhage (SAH) carries a 50% mortality rate. The extravasated erythrocytes that surround the brain contain heme, which, when released from damaged red blood cells, functions as a potent danger molecule that induces sterile tissue injury and organ dysfunction. Free heme is metabolized by heme oxygenase (HO), resulting in the generation of carbon monoxide (CO), a bioactive gas with potent immunomodulatory capabilities. Here, using a murine model of SAH, we demonstrated that expressi ...[more]