Ontology highlight
ABSTRACT:
SUBMITTER: Dhawan S
PROVIDER: S-EPMC4563682 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Dhawan Sangeeta S Tschen Shuen-Ing SI Zeng Chun C Guo Tingxia T Hebrok Matthias M Matveyenko Aleksey A Bhushan Anil A
The Journal of clinical investigation 20150622 7
Pancreatic β cells secrete insulin in response to postprandial increases in glucose levels to prevent hyperglycemia and inhibit insulin secretion under fasting conditions to protect against hypoglycemia. β cells lack this functional capability at birth and acquire glucose-stimulated insulin secretion (GSIS) during neonatal life. Here, we have shown that during postnatal life, the de novo DNA methyltransferase DNMT3A initiates a metabolic program by repressing key genes, thereby enabling the coup ...[more]