Ontology highlight
ABSTRACT:
SUBMITTER: Kramann R
PROVIDER: S-EPMC4563736 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Kramann Rafael R Fleig Susanne V SV Schneider Rebekka K RK Fabian Steven L SL DiRocco Derek P DP Maarouf Omar O Wongboonsin Janewit J Ikeda Yoichiro Y Heckl Dirk D Chang Steven L SL Rennke Helmut G HG Waikar Sushrut S SS Humphreys Benjamin D BD
The Journal of clinical investigation 20150720 8
Chronic kidney disease is characterized by interstitial fibrosis and proliferation of scar-secreting myofibroblasts, ultimately leading to end-stage renal disease. The hedgehog (Hh) pathway transcriptional effectors GLI1 and GLI2 are expressed in myofibroblast progenitors; however, the role of these effectors during fibrogenesis is poorly understood. Here, we demonstrated that GLI2, but not GLI1, drives myofibroblast cell-cycle progression in cultured mesenchymal stem cell-like progenitors. In a ...[more]