Ontology highlight
ABSTRACT:
SUBMITTER: Voon YL
PROVIDER: S-EPMC4564086 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Voon Yee-Lin YL Ahmad Munirah M Wong Pooi-Fong PF Husaini Roslina R Ng Wayne Tiong-Weng WT Leong Chee-Onn CO Lane David Philip DP Khoo Alan Soo-Beng AS
Oncology reports 20150805 4
The small-molecule inhibitor of p53-Mdm2 interaction, Nutlin-3, is known to be effective against cancers expressing wild-type (wt) p53. p53 mutations are rare in nasopharyngeal carcinoma (NPC), hence targeting disruption of p53-Mdm2 interaction to reactivate p53 may offer a promising therapeutic strategy for NPC. In the present study, the effects of Nutlin-3 alone or in combination with cisplatin, a standard chemotherapeutic agent, were tested on C666-1 cells, an Epstein-Barr virus (EBV)-positiv ...[more]